Both of these sell a GLP-1 you do not inject, and both have documentation problems — but not the same size of problem.
Telos Rx is far cheaper: sublingual tirzepatide at $129 a month against Synergy Rx’s oral dissolving tablet at $299, and injectable semaglutide at $99 against $199. What it does not publish is a price for any specific plan length, and the footer link labelled “Pricing” points at an anchor that does not exist.
Synergy Rx is worse on disclosure in a way that matters more. It states no billing period anywhere — not next to any price, and its terms of use contain no mention of subscriptions, renewals or monthly billing at all. All sales are final, consultation fees are non-refundable, and no refund window is published. Its terms also refer to a “CareGLP portal” rather than to Synergy Rx.
Read our Telos Rx review →Synergy Rx — see current options ↗
Neither link above is an affiliate link: the Telos Rx button leads to our own review, and Synergy Rx’s affiliate program was paused when we checked on 28 September 2026.
Side by side
| Telos Rx | Synergy Rx | |
|---|---|---|
| Needle-free option | Daily sublingual tirzepatide, as low as $129/month. Also a microdosed tirzepatide at $116 | Semaglutide oral dissolving tablet, from $299 — the only dissolving tablet in this comparison |
| Injectable semaglutide | As low as $99/month | From $199 |
| Injectable tirzepatide | As low as $139/month | From $349 |
| Billing period stated? | No price published for any specific plan length. The footer “Pricing” link points at a missing anchor | No billing period stated anywhere. The terms of use never mention subscriptions, renewals or monthly billing |
| Refunds | See our Telos Rx review for the published terms, including the cancellation re-pricing rule and the eligibility refund | All sales final, consultation fees non-refundable. No refund window published |
| Other oddities | Sells a long list of compounded peptides alongside the GLP-1s | Terms refer to a “CareGLP portal” rather than to Synergy Rx |
| FDA status | Compounded, not FDA-approved | Compounded, not FDA-approved |
Neither oral option is FDA-approved, and that is the important part
There is an approved oral semaglutide — Rybelsus. Neither of these is it. Both are compounded preparations the FDA has not reviewed for safety, effectiveness or manufacturing quality, and there is no FDA-approved oral tirzepatide in any form, so Telos Rx’s sublingual tirzepatide has no approved counterpart at all.
Semaglutide is a peptide, and peptides are poorly absorbed through the gut, which is why the approved oral version uses a specific absorption enhancer and a strict fasting protocol. A compounded sublingual or dissolving preparation is not that formulation. Neither company publishes absorption data. Our oral and sublingual comparison goes through this in more detail.
So the honest framing is that you are paying a premium for a format whose performance is not documented by either seller.
Synergy Rx’s missing billing period
We would rather flag this than rank it, because it is not a price problem, it is a documentation problem.
Synergy Rx publishes prices with no billing period attached. “From $199” could be a month, a term or a one-off, and its terms of use resolve nothing — they do not mention subscriptions, renewals or monthly billing at all. Combined with all sales being final, no published refund window, and terms that name a different brand, there is no document on that site that tells you when or how often your card will be charged.
That is the single most consequential gap we found across all sixteen providers, because it is the one you cannot resolve by reading more carefully. If you buy from Synergy Rx, get the billing interval confirmed in writing before you pay, and screenshot the checkout screen.
Telos Rx’s gap is smaller but real
Telos publishes as-low-as prices and nothing else. There is no price for any specific plan length anywhere on the site, and the footer link labelled “Pricing” points at an anchor that does not exist — so the one place you would go to resolve the ambiguity is broken.
The difference from Synergy is that Telos does publish shipping, returns and cancellation terms, so the rules that govern your money exist in writing even though the price ladder does not.
Which one to pick
Telos Rx, on both price and documentation. Its sublingual tirzepatide at $129 is less than half Synergy Rx’s $299 tablet, its injectables are cheaper on both molecules, and it publishes the terms that decide what happens to your money. Treat the as-low-as figures as a floor rather than a quote, and confirm your actual plan price before paying.
Synergy Rx only if the dissolving tablet specifically is what you want, since it is the only one in this comparison. Even then, get the billing interval in writing first.
If needle-free is a preference rather than a requirement, both companies’ injectables are cheaper than their oral products, and the injectable market is far better documented.
Read our Telos Rx review →Trimi — $99 flat, fully documented ↗
The Trimi link is an affiliate link; the Telos Rx button leads to our own review. Ordering on this site is never sold; see our affiliate disclosure.
Compare this against the rest of the market
- Full Telos Rx review
- Full Synergy Rx review
- Oral and sublingual GLP-1s compared
- Compounded tirzepatide prices compared
- Compounded versus FDA-approved GLP-1s